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Studies show that adequate intake of B12 (along with other B vitamins) can help lower the risk of fractures, especially in older adults

4 Se-SP also counteracts 8-hydroxy-2-deoxyguanosine lesions, which limit comet-assayed strand breaks and increase the expression of base-excision repair enzymes like 8-oxoguanine DNA glycosylase

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However, in another intervention trial with combination therapy (53), the risk of adverse effects was significantly higher in the Se supplementation group, which we speculate may be related to unclear baseline Se levels in the subjects and a narrower safety window during Se treatment

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