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Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol)

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The committee made two general recommendations: first, to continue to develop better animal models, and second, to identify biomarkers of injury and improved brain function

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In this context, chronic hypoxia treatment has shown some promise in various preclinical models of Friedreichs ataxia, indicating a key role for oxygen in the pathogenesis 173,174

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