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Tirzepatide is already available as both Mounjaro and Zepbound

However, some patients experience persistent symptoms that may limit medication tolerance or necessitate discontinuation

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Misaligned expectations are the most common reason patients discontinue prematurely

In normal esophageal epithelium, moderately activated TLR2 up-regulated the tight junction complexes kelotanin-1 and occluding zona pellucida-1, which enhanced the function of the esophageal epithelial barrier (46)

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