the boxed warning for thyroid C-cell tumors applies to both semaglutide and tirzepatide based on rodent studies, so a personal or family history of medullary thyroid carcinoma or MEN-2 is a contraindication for both
The uneducated clinicians will say, you dont have Intrinsic factor antibodies (IFA) so you dont have pernicious anaemia (PA) and so you will stay on tablets because we decided you can now miraculously absorb B12 from food! This ludicrous concept crops up frequently (I have blogged about it before here.) It needs repeating so often PA is just one of many causes and they are all serious and need correct treatment
The offer is there for us to help however we can, but you would need to provide us with the information we would need for our help to be effective.
Mol Pharmacol 65:528537 [DOI] [PubMed] [Google Scholar] Charlton JJ, Allen PB, Psifogeorgou K, Chakravarty S, Gomes I, Neve RL, Devi LA, Greengard P, Nestler EJ, Zachariou V
THIS IS NOT REAL MEDICATION
Quinine-containing beverages may cause health problems