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Here, we utilized brain-targeted LNP loaded with a novel Hv1 channel inhibitor, YHV984, to effectively alleviate the neuroinflammatory response post-IS

While your body can use those amino acids to try and rebuild glutathione internally, this process is inefficient and slow

Your body produces glutathione naturally, and it is found in almost every cell

Glutamate exposure in rat hippocampal neurons triggers a sustained elevation of extracellular adenosine triphosphate (ATP) levels, subsequent activation of P2Y1 receptors (P2Y1R), and ultimately results in hippocampal neuron death [46]

38 The switch of MAT1A to MAT2A/MAT2B reduces the levels of SAM, which is an essential factor in fibrosis and liver cancer

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