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Without the mechanical stimulus of progressive overload, the body has no reason to preserve muscle during caloric restriction

Consider treatment response and tolerability when selecting the maintenance dose Pen administration 1 Patients should administer Wegovy or Wegovy HD once weekly, on the same day each week, at any time of day, with or without meals Wegovy and Wegovy HD should be injected subcutaneously in the abdomen, thigh, or upper arm

Of the weight lost, about 25 lb consisted of fat mass and 2.4 lb was muscle mass

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When participants were started directly at 8 mg instead of titrating from 1 mg, GI symptom rates nearly doubled