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Prolonged deficiency allows more extensive damage to accumulate, particularly to the nervous system, which requires longer to repair
However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use
Its ability to interact with lipolytic pathways without the confounding growth-promoting effects of full GH makes it particularly useful for dissecting the metabolic arm of GH signalling in laboratory models
Researchers use AOD 9604 in adipocyte assays, biochemical studies, and preclinical models to investigate lipolysis, fatty acid mobilization, and metabolic pathway regulation without activating the full growth hormone signaling cascade
Mar 2012;39(2 Suppl 2):S1-59