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Age-related changes in renal function, hepatic metabolism, and tissue perfusion theoretically could influence peptide clearance and distribution, though no studies have systematically examined age effects

Consider adding electrolytes if diarrhea is frequent

Peer review Peer review information Nature Reviews Drug Discovery thanks the anonymous reviewers for their contribution to the peer review of this work

The blood pressure benefits emerge through several interconnected pathways

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Symptoms of hypoglycemia are shakiness, sweating, dizziness, confusion, and even loss of consciousness