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An exclusive license for commercial development of these amino acid substitutions enabled argenx to build on the pioneering work by Ward and create a novel Ab-based molecule by removing the Fab arms of the full-length IgG1 used in the proof-of-concept studies [115, 119,120,121]

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To guarantee the therapeutic levels of Glp-l, scientific research has undertaken three ways producing: - Analogs of Glp-1: molecules of Glp- slightly modified to allow adhesion to the blood proteins and therefore make them resistant to the action of Dpp-4

This limitation is particularly critical for East African countries, where agriculture and hydropower generation depend heavily on rainfall, making societies highly vulnerable to variability and extremes

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and short follow-up durations that are insufficient to assess long-term efficacy or relapse