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5 Discussion and future directions The prevailing view that IF is cardioprotective largely stems from experimental rodent models and intervention studies ( A major goal for future research will be to identify dietary interventions that both optimally support patients with obesity during pharmacotherapy and maintain the metabolic and cardiovascular benefits achieved during treatment

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Mol Cells 2008

doi:10.1016/j.dsx.2022.102421

When contemplating whether to perform limb-sparing versus limb-sacrifice procedures, it is important to consider that for MPNSTs at the level of the plexus, amputation offers superior survival as compared to local resection if an R0 resection is not possible [49,54]

On the basis of these findings, a clinical study program was started to investigate the efficacy and safety of tirzepatide in the treatment of obesity and obesity management