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Koller KJ, Coyle JT

As your protocol concludes or transitions, we discuss sustainability

Whether pharmacological TREK-1 blockade (which is partial and reversible, unlike genetic knockout) carries seizure risk at therapeutic doses is unknown

Tips for Managing Side Effects Eat smaller, more frequent meals Avoid fatty, greasy, or heavily processed foods Stay well hydrated Support your gut health with fiber and probiotics Communicate with your provider about symptom severity Important Safety Information The prescribing information includes a boxed warning about the risk of thyroid C-cell tumors, based on animal studies

All authors checked the study and agreed to participate in the manuscript

Nat Rev Endocrinol 20 , 447459 (2024)