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Common side effects are generally mild and may include temporary injection site irritation, headache, or flushing

The current understanding of pharmacotherapy in BED, however, remains limited due to gaps and methodological limitations in the literature [4]

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More importantly, oxidant enzymes including mitochondrial electron transport chain complex I, complex II, complex III, as well as SODs, xanthine oxidase (XO), NO synthases (NOS), cytochrome p 450 enzymes (CYP), NADPH oxidases (NOX) and lipoxygenase (LOX), generate O 2 radicals which are quickly converted into H 2 O 2 , OH and other radicals [26]

The phase 3 trials also tested a 4mg maintenance dose in addition to the 9mg and 12mg doses

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