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The synthesis method of the acylated GLP-1 compound and modified gene thereof is characterized by comprising the following steps of preparing a compound 2, namely, taking GLP-1 (9-37) as an initial raw material, carrying out PEG medication by a compound 1 on Lys of a position 26 of a relative sequence GLP-1 (9-37), controlling the reaction pH and carrying out an acylation coupling reaction to obtain a compound 2

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The nucleotide sequence of semapeptide (nucleotide sequence) is: GAG GGC ACC TTC ACC AGC GAC GTT AGC AGC TAT CTG GAG GGC CAG GCG GCG AAA GAA TTT ATT GCG TGG CTG GTT CGT GGT CGT GGC

Both are GLP-1 agonists, but are synthesized differently

Biological synthesis requires more development time to set up the strains and scale

By using a short peptide chain Fmoc-Thr -Ser -Asp -OH, impurity deletion caused by the a 14 locus Ser difficult reaction locus is directly avoided