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In a phase 2 trial, 43% to 100% of participants experienced at least a 50% reduction in liver fat, and 32% to 93% achieved at least a 70% reduction

Nrf2 is a major regulator of the cellular oxidative stress response and maintenance of redox homeostasis ( 2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation ( Dysfunctional mitochondria release into the cytoplasm, it binds to with Apaf-1, triggering caspase-9, caspase-3 related cascade reactions that lead to apoptosis (Figure 2)

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Her past medical history included hypertension, dyslipidemia, and right adrenal enlargement, with no prior neurological disorders

doi: 10.1016/j.jid.2019.03.1165 19 ChenJLiSLiC

Cystine-free/CysGly-supplemented = 9, from 4 independent experiments