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dissected GLP-1R-expressing lumbar dorsal root ganglion neurons from mice and cultured them with Schwann cell-conditioned media to mimic diabetic conditions ( in vivo experiments, the authors treated the streptozotocin-induced DM mice with exendin-4 at 10 nmol/kg for 4 weeks and found that exendin-4 promoted the peripheral nerve function as reflected by improved current perception threshold and motor and sensory nerve conduction velocity
242 The expression of GLP-1R on -cells helps to inhibit the secretion of glucagon
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These compounded GLP-1 drugs may include custom microdose formulations, and some are marketed for off-label uses like longevity or cognitive support, though experts warn that their safety and effectiveness remain unproven
This is risky and not recommended, as compounded GLP-1 medications are linked to cases of hospitalizations , the FDA warns
