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HUBERMAN: Within the milieu of the gut, you have a lot of turnover of cells

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You develop signs of an allergic reaction, such as swelling, redness, itching, or a rash

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Temperature cycling, repeatedly moving between refrigerator and room temperature, accelerates degradation beyond what either constant temperature would cause

In that case, stop using the product right away (if its a topical, gently wash it off with cool water) and seek prompt medical attention