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Grimes PE, Bhawan J, Howell MD, Desai S, Coryell E, Nashawati R, et al

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The novel mechanism by which 4-HNE inhibits NLRP3 is through its ability to directly bind to the critical domains of NLRP3, disrupting its interaction with the adapter protein NEK7, a key step in inflammasome activation, thereby preventing caspase-1 activation