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Shwartz y colaboradores proponen el llamado onceno atroz (Figura 3) que pone como principal elemento la anormalidad de la clula beta ms disminucin en su nmero, con un esquema donde hay interaccin de predisposicin gentica, resistencia a la insulina, elementos ambientales, estilo de vida y respuesta inmuno/inflamatoria alterada

Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation

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coli , explained by the higher proportion of antimicrobial metals within the Al phase (Hahn et al., 2018)