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People with obesity have higher baseline levels of GLP-1 but less variability, especially if they also have metabolic syndrome or diabetes

There can be fluctuations in hormone levels, leading to potential highs and lows, which may result in mood swings, irritability, or other hormonal imbalances

Researchers emphasized that this non-invasive route could serve as a model for other neuroactive synthetic peptides, providing a foundation for future translational studies on neurodegenerative conditions

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DHCA and Mal-gluc, as externalizing metabolites of bioactive dietary polyphenol compounds, have been associated with depression [98], and in addition to modulating neurexins and synaptic plasticity, studies on their further sustained antidepressant activity should follow