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They have not been studied in the clinical trials behind those medications

Brzozowski et al., Comparison of nitric oxide-releasing NSAID and vitamin C with classic NSAID in healing of chronic gastric ulcers

[25] Some patients also use herbal antihistamine supplements such as quercetin or take diamine oxidase (DAO), an enzyme normally produced by the body that breaks down histamine, as a supplement

Yes B12 is watersoluble, and excess amounts are excreted naturally

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Yet, most patients find the treatment approachable when factoring in health benefits and available payment tools