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Lukyanov and Belousov, 2014

elegans ages, intestinal nuclei are lost (McGee et al., 2011) and the propidium iodide cannot stain nuclei if they are absent

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The metalloproteinase pregnancy-associated plasma protein A2 (PAPP-A2) is involved in the proteolysis of the IGF-1 ternary complex, releasing free and active IGF-1 on target tissues [113]

This limits their ability to repair oxidative damage, making DNA fragmentation particularly harmful

(IntechOpen, Rijeka), Ch