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desensitization is unclear if used beyond saturation dose

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Funding This work was supported by grants from the Chung Shan Medical University Hospital (CSH-2020-C-016)

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Mechanisms of action documented in RUO research IGF-1R receptor activation IGF-1 LR3 binds the IGF-1R tyrosine kinase receptor with nanomolar affinity, similar to native IGF-1

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