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Genes identified by at least two of the three algorithms were defined as key candidate genes for downstream pathway enrichment and functional analyses

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Glutathione depletion impacts the gamma glutamyl cycle in the liver by increasing the activity of -glutamyl cysteine synthetase and accumulation of -glutamyl cysteine, which is converted by -glutamyl cyclotransferase to pyroglutamic acid/5-oxyproline [3, 4] (Fig

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