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Study 2 was a 68-week trial that enrolled 1,961 patients with obesity (BMI greater than or equal to 30 kg/m2) or with overweight (BMI 27 to 29.9 kg/m2) and at least one weight-related comorbid condition, such as treated or untreated dyslipidemia or hypertension

Clinical data suggests that semaglutide works best when combined with consistent physical activity and nutritious eating patterns

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References: [2]

This physiological pattern is associated with better efficacy and fewer side effects

Tirzepatide helps keep both signals active across the week rather than allowing them to fade within minutes