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Calcification can be observed on MRI scans, particularly in patients who have experienced a stroke or traumatic brain injury, and this calcification may be related to the deterioration of melatonin synthesis, which decreases dramatically with age, potentially leading to issues such as precocious puberty in some cases 10s

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certain allelic variants of several genes have been associated with an increased risk of essential hypertension, and almost all cases are known to be related to a familial history of hypertension (135)

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For many, chronic body aches and fatigue can lead to emotional distress, affecting mood and overall quality of life