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The average person produces 0.5 to 1.5 liters of saliva per day, with flow rates that vary based on hydration status, time of day, and stimulation from food or flavored formulations

Examples: Azelastine, Olopatadine

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The activity of ABC transporters accumulates them in the vacuole, thereby restricting the circulation of free Cd 2+ within the cytosol, and they complex Cd ions through the thiolic group (SH) of cysteine (Salbitani et al., 2023)

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However, studying exactly how it works is difficult