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Second, future trials should standardize timing (pre-treatment vs stimulation-only), dosing (e.g., 35 mg nocte), and core outcomes (ongoing pregnancy, live birth), and incorporate follicular-fluid redox readouts to confirm target engagement in PCOS

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The first responds to nutrient-related signals, while the second is activated by hormonal signals and vagal nerve activity

In addition, the professor said that only about 40% of patients maintain the use of the drug after a year, and emphasized that for diabetic and obese patients, regardless of treatment with any medication, it is still necessary to develop and maintain a healthy lifestyle to control the disease at the best level

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