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Synthesis and biological properties of -glutamyl-dermorphin, a prodrug

Rising intracellular calcium levels may drive the fusion of growth hormone-containing vesicles with the plasma membrane, facilitating the release of growth hormone into the extracellular environment

In mitochondria, SIRT4 is reported to not only suppress malonyl-CoA carboxylase to inhibit fatty acid oxidation, but also repress pyruvate dehydrogenase and stimulate mitochondrial ATP production [123]

Considering their low MW and non-covalent nature of inhibition of TGR, these compounds were deemed appropriate for fragment-based design

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