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For 90 Y-DOTATOC and 177 Lu-DOTATATE doses less than 40 Gy were safe for patients without any risk factors, while for patients with risk factors for CKDmainly hypertension and diabetesa threshold of 28 Gy was recommended [54]

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Furthermore, the authors reported that the MCF-7 breast cancer cell line shows an E2-dependent increase in its survival rate, which is abrogated by pre-treating them with the anti-estrogenic compounds ICI-182, 780, or raloxifene (Yu et al., 2012)

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Moreover, besides the enhanced activity of fibroblasts, which are considered essential for collagen synthesis, tissue repair, and regeneration, there was also a potential rise in mast cell activation

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