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GLP1-RA reduced the risk of the broad composite kidney outcome significantly by 17% which was only driven by a reduction in macroalbuminuria (26% reduction)

While these pharmacovigilance findings underscore the need for heightened clinical vigilance, they represent associations rather than causal relationships, constrained by inherent limitations of FAERS such as reporting bias and confounding

An enzyme called lipoyl (octanoyl) transferase 2 catalyzes the transfer of the octanoyl moiety from octanoyl-ACP to a conserved lysine of the H protein of the glycine cleavage system (see also Biological Activities)

doi:10.1016/S0140-6736(21)01324-6 15

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