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Herein we address recent findings that demonstrate how disrupted carnitine metabolism informs the phenotypes of several major diseases (see Table 1), potentially elucidating mechanistic pathways that could provide pharmacodynamic targets
However, factors like stress, aging, poor diet, and environmental toxins can deplete glutathione levels
A human retrospective cross-sectional analysis of 1477 women suggests that adequacy of dietary choline/betaine may be important for individuals with a lower folate intake or where the folate cycle is reduced due to SNPs or high alcohol consumption (lowering folate status) because the betaine-remethylation pathway of homocysteine is able to go someway to compensate for the folate re-methylation pathway (Chiuve et al , 2007)
