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The authors noted the strength and consistency of preclinical findings and called for properly designed human trials

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However, optimal multi-compound stacking protocols for AOD-9604 remain unvalidated in human trials

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Hydroxocobalamin may also be given intravenously in certain scenarios (for example, 5 g IV for acute cyanide poisoning antidote therapy), but such high-dose use is in emergency settings and distinct from routine deficiency treatment