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Since 2005, when the first GLP-1 medication, exenatide, was approved, the class has evolved with more effective and longer-acting options

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(34) However, the focus of this review was primarily on the cardiovascular and renal benefits of these therapies, with little to no emphasis on musculoskeletal outcomes

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This effect was mediated by the activation of protein phosphatase 2A (PP2A) and the subsequent dephosphorylation of specific Tau epitopes in SHSY5Y cells expressing the human Tau subtype (Figure 5A) [107]