According to the 2024 European Society of Cardiology Guidelines for the Management of AF, hypertension, heart failure, T2DM, and obesity are recognized as risk factors contributing to both the onset and progression of AF [41]
The clinical evidence for Rhodiola rosea is supported by multiple randomized, double-blind, placebo-controlled trials, including a phase III study evaluating the standardized extract SHR-5, which demonstrated statistically significant improvements in depressive symptoms with a favorable tolerability profile
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This activates caspase-9 and enhances caspase-3-mediated degradation of nuclear and cytoplasmic structures
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