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Biol Psychiatry 2001

Earlier studies have demonstrated that IL-1 and IL-18 not only promote atherosclerosis progression but also contribute to advanced plaque instability and myocardial infarction (50)

That can increase the risk of losing lean muscle along with body fat

The results showed that inhibiting HDAC5 significantly increased CD8 + T cell infiltration in the tumor microenvironment, reduced the proportion of Tregs, and exhibited synergistic effects with anti-PD-1 antibodies, jointly inhibiting tumor growth (69)

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