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In addition, DKT was found to suppress the visceromotor response to colorectal distention in rats treated with DSS and TNBS

Sample size was determined based on feasibility and consistency with prior exploratory pharmacokinetic studies [22,44]

doi: 10.1096/fj.01-0376com

With respect to hypertension, several in vivo studies have provided evidence that eNOS uncoupling occurs in animal models of increased blood pressure, including ATII hypertension, 14 DOCA-salt induced hypertension, 57 NOX1 upregulation 83 and genetically determined hypertension 84 in which an uncoupled eNOS was consistently identified as a significant superoxide source

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