22 Gouvrion et al studied 66 patients with HS who were treated with a GLP-1RA for at least 3 months, with a median follow-up time of 18.5 months
The ultra-long half-life may eliminate the need for dose titration, which would be a significant convenience advantage over current GLP-1 therapies
MASH is a chronic condition, and stopping GLP-1s often reverses progress
At the age of 11.64 the growth velocity was above normal values for age (SDS 2.8)
RNA-seq data from a randomly down-sampled (balanced) cohort of CLL/N WT (n = 50) and CLL/N M (n = 50) [33] confirmed that NOTCH1 signaling pathway was significantly enriched in CLL/N M cells (NES = 1.52, FDR = 0.106, Fig
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