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Clinical studies using ultramicronized PEA-LUT have administered 100600 mg/day luteolin equivalents for 212 weeks without any serious adverse events ( Several pharmacokinetic considerations warrant attention

doi: 10.1177/074873049701200620

Most daily formulations are taken once daily at any time, with or without food, though maintaining the same approximate time each day helps optimise effectiveness

Bedaiwy MA, Dahoud W, Skomorovska-Prokvolit Y, Yi L, Liu JH, Falcone T, Hurd WW, Mesiano S (2015) Abundance and localization of progesterone receptor isoforms in endometrium in women with and without endometriosis and in peritoneal and ovarian endometriotic implants

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