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Typical murine plasma half-life: 4-8 hours after subcutaneous injection (vs 10-20 minutes for native IGF-1)

Room temperature storage significantly reduces shelf life

And mitochondrial dysfunction is a hallmark of virtually every neurodegenerative disease

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The circadian rationale remains the same, but older adults (50+) show reduced amplitude of the endogenous nocturnal GH pulse, making the peptides amplification effect even more critical

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