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One of the rare (but potentially underdiagnosed) causes of anion gap metabolic acidosis is acquired 5-oxoprolinuria due to excessive Tylenol ingestion

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In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/P)-induced Parkinsons disease model mice, MPTP/P injection increased the ratio of Bax/Bcl-2 and the expression of caspase-3 in the hippocampus, while berberine administration reversed these effects (Kim et al., 2014)

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a transdermal patch of GHK-Cu peptide is developed

NNMT is an enzyme involved in nicotinamide metabolism and energy-related pathways