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Taking ADCs as an example, early evaluation of plasma stability in in vitro studies should be prioritized, with comprehensive biological analyses conducted on in vivo samples (ADC/total antibody/free payload/linker payload metabolites) and performing anti-drug antibody (ADA) assessments and tissue/tumor exposure evaluations to characterize the drug's ADME characteristics while monitoring liver function and DDI risks

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Research indicates that it contributes to a reduction in body weight of 5.8 kg in 47.5% of the subjects over a year, compared to a weight reduction of 2.2 kg in 20.3% of the subjects in the placebo group

berghei GFP-Luc ama 1 (1037cl1) parasite line was used to assess antiplasmodial activity of ChemBridge Hit2Lead library compounds (CB compounds) and the half-maximal effective concentration (EC 50 ) by in vitro drug luminescence assay as previously described (Lin et al., 2013)

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