Like too much B12, low MMA so far has no known health risks
How much of the administered dose actually reaches systemic circulation to inhibit NNMT
It supports adult brain and nervous system health and contributes to memory, learning, mood regulation and energy levels
Nelson Textbook of Pediatrics (20th ed.)
Medications in this category include: Metformin, H2 blockers and PPI (proton pump inhibitors) used to block acid production in the GI tract
Additionally, chronic conditions such as HIV and tuberculosis have been implicated in B12 deficiency due to increased metabolic demand and altered absorption mechanisms ( The diagnosis of vitamin B12 deficiency typically relies on low total B12 levels and elevated concentrations of homocysteine (Hcy), as well as levels of transcobalamin-bound B12 (holoTC) and methylmalonic acid (MMA), which serve as functional indicators of cobalamin insufficiency ( Vitamin B12 requirements fluctuate throughout the life course, influenced by metabolic demand and physiological changes