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Lixisenatide administered to pregnant rats and rabbits during organogenesis was associated with visceral closure and skeletal defects at systemic exposures that decreased maternal food intake and weight gain during gestation, and that are 1-time and 6-times higher than the 20 mcg/day highest clinical dose, respectively, based on plasma AUC [see Data]

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(2021) 22(1):e13112

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Patients should seek urgent medical attention for severe persistent abdominal pain, as pancreatitis and biliary disease remain potential risks even after gallbladder removal