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A large meta-analysis of 45 RCTs recently found that compared with placebo or other interventions, GLP-1RAs did not increase the risk of thyroid cancer, hyperthyroidism, hypothyroidism, thyroiditis, thyroid mass, and goiter [69]

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Kim JA, Lee S, Lee SH, Jung SY, Kim YH, Choi IY, et al

similar pharmacokinetic characteristics are observed in Sprague-Dawley rats (100 mg/kg, subcutaneous injection, single dose), with a plasma C max of 16800 ng/ml and a half-life of 1.5 hours [3]

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