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Gastrointestinal Secretions Farmacocintica Absoro: via oral Distribuio: Extensa Ligao a protenas varivel Metabolismo: Varivel Heptico Alguns pelo sistema do citocromo P450 Excreo: Principalmente pela urina Exceo: A linagliptina excretada principalmente pelas fezes

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Nature 476 (7360), 293297

CR enhances the proliferation of Lgr5+ intestinal stem cells, the cell-of-origin for intestinal precancerous adenomas and leads to the first organoid and acceleration of the second organoid formations (11,21)

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