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Although there may be concerns with its bioavailability in the brain, we have previously proved that intra-nasal delivery can be a viable route to counter this potential obstacle [73]

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TNF- drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice

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In this model we exposed BALB/c mice to Alternaria alternata and treated them with melatonin both at 17:00, since this is a time point that has been found to result in the most severe induction of features of allergic airway pathology (42)

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