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Peptides synthesized with even single amino-acid substitutions lose receptor binding affinity and therapeutic effect

FG-4592, a novel oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), maintains hemoglobin levels and lowers cholesterol in hemodialysis (HD) patients: phase 2 comparison with epoetin alfa [abstract]

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Analgesia, antidepressants and calcium channel blockers are historically amongst the common culprits, with a recent increase seen in the use of recreational drugs (including so-called legal highs) and medication sold on the internet for weight loss