A Doctors Perspective As a physician with nearly two decades of experience prescribing these medications, heres my balanced take on who should consider GLP-1 treatment: Ideal Candidates: The Persistent Struggler : Youve consistently eaten well and exercised but still cant lose weight The Metabolic Challenger : You have insulin resistance, pre-diabetes, or metabolic syndrome The Health-Focused : Your weight is causing health issues like joint pain, sleep apnea, or high blood pressure The Committed Planner : Youre ready to combine medication with nutrition, exercise, and lifestyle changes Important Considerations: Results Potential : These medications can deliver weight loss comparable to bariatric surgery for many patients
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Conversely, patients who carry variants in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, rs72613567) and mitochondrial amidoxime-reducing component 1 (MARC1, rs2642438) are more protected than the general population (48, 49)
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