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doi: 10.3389/fonc.2019.00247 54 MogaveroAMaioranaMVZanuttoSVarinelliLBozziFBelfioreAet al

Diabetes is characterized by chronic systemic hyperglycemia, which activates several secondary metabolic pathwayssuch as the polyol pathway, accumulation of AGE products, and protein kinase C (PKC) activationthat contribute to retinal and systemic vascular damage [67]

Think of it like loosening a clamp on a pipe flow increases, but the effect is specific to that vascular tissue type and hasnt been shown to generalize beyond it

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

Your body naturally accumulates more fat as you get older

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