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Tesofensine produced weight loss significantly greater than placebo and was more effective than any currently approved obesity drug at the time. Astrup et al., The Lancet Additional Findings: The majority of weight loss came from visceral fat and abdominal adiposity Lean body mass was preserved , unlike with most appetite suppressants Participants reported reduced hunger and better diet adherence Tesofensine significantly improved waist circumference , lipid profiles, and fasting glucose These findings have led to continued interest in Tesofensines use for body recomposition not just for general weight loss, but for fat-specific reduction without muscle sacrifice
[archived link] Can New Drugs Help Millions of Americans with Obesity
These results show that new medical therapies can help bridge that gap. The findings come amid a skyrocketing interest in GLP-1 medications
Eli Lillys tirzepatide uses synthetic versions of GLP-1 and gastric inhibitory polypeptide
Both routes end in growth hormone release, but they start from different doors